GOAT ANTI ErbB3 (C-TERMINAL) Antibody

Name

GOAT ANTI ErbB3 (C-TERMINAL) Antibody

Size

100ug

Catalog number

MBS221381

Price

481 EUR

More details

Alternative name1

Anti-GOAT ANTI ErbB3 (C-TERMINAL)

Alternative name2

Caprine ANTI ErbB3 (C-TERMINAL)

Alternative name3

Caprinae ANTI ErbB3 (C-TERMINAL)

Alternative name4

ErbB3

Alternative name5

N/A

Other names

receptor tyrosine-protein kinase erbB-3 isoform s; Receptor tyrosine-protein kinase erbB-3; receptor tyrosine-protein kinase erbB-3; proto-oncogene-like protein c-ErbB-3; tyrosine kinase-type cell surface receptor HER3; v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian); Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3

Gene name

ErbB3

Gene name synonims

N/A

Other gene names

ERBB3; ERBB3; HER3; LCCS2; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3; HER3

Category

Antibodies

Clonality

Polyclonal

Immunoglobulin isotype

Polyclonal IgG

Clone

Polyclonal antibody

Host organism

Goat

Species reactivity

Human

Specificity and cross-reactivity

ErbB3 This item detects an epitope within the C-terminal (CT) region of ErbB3 isoform 1. ErbB3 is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases, and has a molecular weight of 150kD. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain, and can therefore only convey the signal through heterodimerisation with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of cellular pathways, thus leading to proliferation or differentiation. _x000D__x000D_Amplification of this gene and/or over expression of its protein has been reported in numerous cancers, including prostate, bladder, and breast tumors. In breast cancer it has been shown to dimerize with ErbB2 to drive tumour cell proliferation.

Purification method

N/A

Form/Appearance

Purified (Purified IgG - liquid)

Concentration

IgG concentration 0.5 mg/ml

Storage and shipping

Store at +Store productone at +4 degrees Celsius. or productone should be stored at -20 degrees Celsius. if preferred. productone should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should productone contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of dispatch.

Tested for:

Western Blot (WB), ELISA (EIA)

Description

productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against. Properly used, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in. Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, they are inexpensive to manufacture and respectively to buy, the time needed for production is considerably shorter. Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions. To obtain more detailed information on productone, please, refer to the full product datasheet.

Advisory

In order to retain the quality and the affinity of productone unchanged, please, avoid cycles of freezing and thawing. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.

Additional description

This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.

Properties

If you buy Antibodies supplied by MBS Polyclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.

Latin name

Capra aegagrus hircus

French translation

anticorps